Solutions refrigerated at 2°≨° C (36°≤6° F) in the dark.Īdverse Effects ( 1%) Body as a Whole: Fever, sepsis, pain, allergic reactions (rare). Diluted solutions are stable for 24 h at 25° C (77° F) in ambient indoor light.If the ACT is >450 sec, decrease infusion rate to 15 mcg/kg/min. Percutaneous Coronary Intervention: Continuous: Start an infusion at 25 mcg/kg/min and give a bolus of 350 mcg/kg, via a large bore IV line, over 3≥ min. Check aPTT 2 h after initiation of therapy to confirmĭesired therapeutic range. Safety and effectiveness in children 100 sec. Cautious Useĭiseased states with increased risk of hemorrhaging severe hypertension GI ulcerations, hepatic impairment pregnancy (categoryī) spinal anesthesia, stroke, surgery, trauma. Any bleeding including intracranial bleeding, GI bleeding, retroperitoneal bleeding. Hypersensitivity to argatroban lactation. Treatment of disseminated intravascular coagulation (DIC). Prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT) prophylaxis or treatment ofĬoronary artery thrombosis during percutaneous coronary interventions (PCI) in patients at risk for HIT. Reversibly binds to the thrombin active site, thereby blocking the thrombogenic activity of thrombin. Capable of inhibiting the action of both free and Synthetic derivative of arginine, which is a direct thrombin inhibitor. ![]() Classifications: blood formers, coagulators, and anticoagulants thrombin inhibitor
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